منابع مشابه
Channelling Evolution
Individuals within a wild population show remarkably little morphological variation, given the amount of environmental variation they encounter during development and the amount of genetic variation within the population. This phenotypic constancy led to the proposal that individuals were somehow buffered, or canalized, against genetic and environmental variation (Waddington 1942). Clearly, suc...
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Very little is known about how animal colour patterns develop. The stripes of the zebrafish provide a tractable a model for colour pattern formation, which now suggests an unconventional patterning mechanism.
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Stoicheiometric analysis of metabolic pathways provides a systematic way of determining which metabolite concentrations are subject to constraints, information that may otherwise be very difficult to recognize in a large branched pathway. The procedure involves representing the pathway structure in the form of a matrix and then carrying out row operations to convert the matrix into 'row echelon...
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We perform an extensive study of several different models of permutation problems proposed by Smith in [Smith, 2000]. We first define a measure of constraint tightness parameterized by the level of local consistency being enforced. We then compare the constraint tightness in these different models with respect to a large number of local consistency properties including arc-consistency, (restric...
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The potential role of Human cytomegalovirus (hCM) infection in promoting neoplasia is an active area of scientific research. [1] Although still controversial, there is a growing body of evidence that links hCMV infection to a variety of malignancies, including those of the breast, prostate, colon, lung and brain (gliomas). [2-7] hCMV induces alterations in regulatory proteins and non-coding RNA...
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ژورنال
عنوان ژورنال: Nature Reviews Cancer
سال: 2013
ISSN: 1474-175X,1474-1768
DOI: 10.1038/nrc3503